Human Physiology
Knowledge of physiology for Medical Student and other health worker.
Monday, January 20, 2020
Human Physiology: METHODS OF CONTRACEPTIONS
Human Physiology: METHODS OF CONTRACEPTIONS: CONTRACEPTIVE METHODS Contraceptive measures are methods used to prevent conception (pregnancy).They include all temporary and permanen...
Dr. Ajay Kumar Singh was born on
2 Dec,1981 in HOLY DISTRICT PRAYAGRAJ. He is an alumnus of
GSVM Medical College Kanpur and
MLN Medical College Allahabad. He worked for 13 years in the Uttar Pradesh Provincial services as Medical Officer.
He offered his services at various place like Community Health Center, Police Hospital, and Jail Hospital. He is a social thinker and writer. He is always ready to deliver his services to the needy person and patient. He works with the motto of making the healthy and happy society.
METHODS OF CONTRACEPTIONS
CONTRACEPTIVE
METHODS
Contraceptive measures are methods used to
prevent conception (pregnancy).They include all temporary and permanent
measures to prevent pregnancy resulting from coitus (sexual intercourse).
Methods of Contraception:-
1. NATURAL METHODS
2. BARRIER METHODS
3. CHEMICAL METHODS
4. LONG-TERM / PERMANENT METHOD
1.NATURAL
METHOD- It is also known as
fertility-based awareness methods. This is the method that uses the body’s natural
physiological changes and symptoms to identify the fertile and infertile phases
of the menstrual cycle.
TYPES:-
A. BASAL BODY TEMPERATURE METHOD
B. CALENDER METHOD OR SAFE PERIOD METHOD
C. LACTATIONAL
AMENORRHEA METHOD
D. WITHDRAWAL METHOD
A).BASAL BODY TEMPERATURE METHOD:- Ovulation raises body temperature by ½ - 1 degree F And temperature
will drop if fertilization does not
occurs.
B).CALENDER METHOD :-Couple avoid or abstain coitus from day 10 to
17 of menstrual cycle when ovulation
could be expected and the chances of fertilisation are very high
during the period , it is called fertility period.
C).LACTATIONAL AMENORRHEA:-Ovulation and menstrual cycle does not occur during intense lactation
following parturition. Increased level of prolactin inhibit production and
secretion of GnRH. Thus decreases the
level of oestrogen in body .Ovulation cannot occur without a surge in oestrogen
level. These methods add chemicals similar to hormones to stop the release of an egg and weaken
the sperm. The hormones change your
cervical mucus and uterine lining,
slow sperm, and reduce ability of fertilized egg to implant
into uterine wall
D).WITHDRAWAL METHOD:- The man takes his penis out of the vagina before ejaculation. Male needs to ejaculate away from female; sperm on legs and labia can
still travel into vagina. Effectivity of this method depends on a male’s self
knowledge and self control. Effectiveness:
78-96%.
2..BARRIER METHODS:-Barrier method of contraceptive prevent the meeting of ovum and sperms after coitus. These
includes
I.
Mechanical Barrier
a.
Male condom
b.
Female condom
c.
Diaphragm
d.
Cervical cap
II.
Chemical Barrier
a.
Spermicides
III.
Combined
a).Male condom:- A thin covering that you unroll over an
erect penis. Made of latex, polyurethane, or animal membrane.
Put on before any genital contact. At withdrawal, hold the rim in place at
the base of the penis so it doesn’t slip
off. It may decrease the sensation for men.
Lubrication makes condom less
likely to break. Effectiveness: 82-98%. Have no side effect and protect against
STD.
b).Female condom:- A soft, loose
pouch that is inserted in the vagina. Flexible
rings at each end hold it in place. Insert
the small ring in vagina, large ring
stays outside partially covering labia. It can be put in up to 8 hours
before sex. It can be used if you are allergic to latex (made of nitrite).Men usually feel no
reduction in sensation. Effectiveness:
79-95%
c).Diaphragm &Cervical cap:- A diaphragm or Cervical cap is a barrier method of contraception
that inside the vagina and prevents sperm passing through the
cervix (the entrance of womb). A gel
that kills sperm (spermicide) need to
use with it.
II).Chemical Barrier:- (Spermicides)- A chemicals that
go in the vagina before sex and they immobilize or kills sperm. It
is mostly work for one
hour . Put in vagina following packaging directions.It need to be put in 10
minutes before intercourse. Nanoxynol-9
and Octoxynol-3 are chemical used as spermicidal agent .Effectiveness: 72-91%.
It
may be
·
Cream
·
Gel
·
Foam
·
Film
·
Suppository
·
Sponge
3.CHEMICAL METHOD:-In this methods chemicals similar to hormones added to stop the release of an egg and weaken the sperm. The hormones change
cervical mucus and uterine lining, slow sperm, and reduce ability of fertilized egg to implant
into uterine wall.
TYPES OF CHEMICAL METHODS
A).STEROIDAL DRUGS
1).The Oral Contraceptive
Pills.
1.COMBINED
PILLS
2.SEQUENTIAL
PILLS
3.MINI PILL
OR MICRO PILL
4.PROGESTERONE
ANTAGONIST
2).Depot
Preparation.
1.
The Patch
2.
Vaginal Ring
3.
The Shot
4.
Sub-dermal Implants.
B).NON STEROIDAL DRUGS
1).Centchroman
C).INTRAUTERINE CONTRACEPTIVE DEVICES
D).EMERGENCY CONTRACEPTIVE
A).ORAL CONTRACEPTIVE PILLS :- The Contraceptive pills (also called birth control pill or "the Pill") is
a daily pill that contains hormones, who prevent the pregnancy by changing the
the body function . Hormones are chemical substances that control the
functioning of the body's organs. In this case, the hormones in the Pill
control the ovaries and the uterus.
TYPES:-
1.COMBINED PILLS
2.SEQUENTIAL PILLS
3.MINI PILL OR MICRO PILL
PROGESTERONE ANTAGONIST
1.COMBINED PILLS: - It contains orally active progesterone (nor-ethioesterone
, norethynodrel, chromodinone) combined with small amount of oestrogen (ethinyl
oestradiol).eg-MALA-D ,MALA-N
2. SEQUENTIAL PILL:-High dose of estrogen for 15 days
followed by 5 days of oestrogen + progesterone . This
inhibits ovulation by suppressing the release of both FSH and LH.
3. MINI PILL OR MICRO PILL:-Low dose of progesterone.
eg- POP (PROGESTIN ONLY PILLS)
4. PROGESTRONE ANTAGONIST:-Producing abortion following the
conception Inhibiting the progestational
effect on uterus.
eg – MIFEPRISTONE
Mode of action of pills:-Pills makes cervical mucus thick
and renders the cervical mucus hostile (unfriendly
) to sperm penetration. It induces
endometrial changes which prevent implantation of blastocyst. By an action or
hypothalamus which inhibits secretion of LH.
DEPOT PREPARATION:- Depot
preparations are long acting drugs and highly effective. These are available
in four forms:
1. The Patch
2. Vaginal Ring
3. The Shot or Injectable preparation.
4.
Subdermal Implants
1.The
Patch:- A bandage-like patch that sticks to skin and it changed weekly. no patch required on
4th week of menstrual cycle. Hormones are absorbed through the skin .It is less
effective body weight over 198 pounds.It may causes skin irritation. Prescription
needed for its application.Effectiveness: 91-99.7%
2.Vaginal Ring:- Vaginal rings containing norgestrel are implanted intravaginally .The
body absorbs hormones from the ring
through vaginal wall.The ring is
inserted and left in the vagina for 3 weeks. Effectiveness: 91-99.7%
3.The Shot: - A long acting hormone injected intramuscularly. Female is given a shot
one time every 3 months. It is non reversible- and once the injection given , the hormones are in the woman for
at least 3 months. It may take a long
time to get pregnant after the shot. More
chance of weight gain than any other
method. Effectiveness: 94-99.8%.It may be two types
i).Oily progestrin preparation
ii).Combined injectable preparation
4.Subdermal Implant:- A soft rod 1 ½ inches long placed under the skin in your upper arm which are slowly releases hormones into your body These are two types
I).Norplant-six flexible silastic tube ,each containing 35mg
progesterone (Levonorgestrel).
ii).Norplant(R)2-two rod of (Levonorgestrel).Implant prevents pregnancy for 3 years, but can be taken out at any time.Effectiveness:
99.95%
B).NON STEROIDAL DRUGS
1).Centchroman:- The new oral contraceptive for the females contain a
non-steroidal preparation developed by
CDRI Lucknow marketed under the trade
name SAHELI. It is once a
week pill” with very few side effects and high
contraceptive value.
C).INTRAUTERINE CONTRACEPTIVE DEVICES:- Implantation of foreign body into uterine
cavity for contraceptive purposes.
1.NON-MEDICATED IUCDs- eg-Lippes loop
2.MEDICATED IUCDs-These
are two types
a).Second generation IUCDs-
eg-Copper T, Coper
T200,NOVA-7,NOVA-T,
multi-loaded
devices.
b).Third generation IUCDs-Harmone releasing IUCDs
eg- PROGESTASERT, LNG 20
D).EMERGENCY CONTRACEPTIVE :- It is also known as Post coital pill or Morning
after pills.A pill or combination of pills which are recommended within 72 hours of unprotected intercourse. It contains a higher dosage (DOUBLE DOSE of
combined pills )of the same hormones
found in regular birth control. It won’t stop an existing pregnancy .Available
at pharmacy for girls 17+, prescription
is needed if less than 17 .Effectiveness is Approx 95% if taken within first 24 hours of unprotected sex, rape or
contraceptive failure.
4).LONG-TERM / PERMANENT METHOD:-
These procedures are
permanent, and are usually done by
people 35+ years, Both procedures are done in a doctor’s office.
1. Female- Tubal
ligation
2. Male- Vasectomy
Female- Tubal ligation :-A small incision is made in the abdomen
to access the fallopian tubes. Fallopian
tubes are blocked, burned, or clipped
shut to prevent the egg from traveling
through the tubes . Recovery usually
takes 4-6 days.
Male- Vasectomy:-A small
incision is made to access the vas
deferens, (the tube through which sperm travels from the testicle to the penis) and is sealed, tied,
or cut.After a vasectomy, a male will
still ejaculate, but there won’t be any
sperm present.
Labels:
METHODS OF CONTRACEPTIONS
Dr. Ajay Kumar Singh was born on
2 Dec,1981 in HOLY DISTRICT PRAYAGRAJ. He is an alumnus of
GSVM Medical College Kanpur and
MLN Medical College Allahabad. He worked for 13 years in the Uttar Pradesh Provincial services as Medical Officer.
He offered his services at various place like Community Health Center, Police Hospital, and Jail Hospital. He is a social thinker and writer. He is always ready to deliver his services to the needy person and patient. He works with the motto of making the healthy and happy society.
Sunday, January 19, 2020
Human Physiology: ABNORMALITIES ASSOCIATED WITH SEX CHROMOSOME
Human Physiology: ABNORMALITIES ASSOCIATED WITH SEX CHROMOSOME: Sex chromosome abnormalities are gender specific. Female abnormalities are due to variation in number of X chromosome .Male abnormali...
Dr. Ajay Kumar Singh was born on
2 Dec,1981 in HOLY DISTRICT PRAYAGRAJ. He is an alumnus of
GSVM Medical College Kanpur and
MLN Medical College Allahabad. He worked for 13 years in the Uttar Pradesh Provincial services as Medical Officer.
He offered his services at various place like Community Health Center, Police Hospital, and Jail Hospital. He is a social thinker and writer. He is always ready to deliver his services to the needy person and patient. He works with the motto of making the healthy and happy society.
Friday, January 17, 2020
ABNORMALITIES ASSOCIATED WITH SEX CHROMOSOME
Sex chromosome abnormalities are gender
specific. Female abnormalities are due to variation in number of X chromosome .Male
abnormalities are due to either the X or the Y chromosome or both.
Sex Chromosomal abnormalities
- Turner’s syndrome
- Klinefelter’s syndrome
- Triple X syndrome
- Testicular feminizing syndrome
- True hermaphrodites
- Developmental abnormalities
1.TURNER’S SYNDROME:- Turner ,s syndrome is also known as gonadal or
ovarian dysgenesis. This is a condition that affects only females, results when
one of the X chromosomes (sex chromosomes) is missing or partially missing.
Turner syndrome can cause a variety of medical and developmental problems.
In This case Karyotype is 45 XO (44 autosome + 1 sex chromosome).This is results
from nondisjunction of one X chromosome.
Characteristics feature-
- Diminish sexual development.
- Webbing of neck.
- Gonadal tissue absent or rudimentary.
- Primary amenorrhea.
- No sexual maturation at puberty.
2.Klinefelter’s
syndrome:- This is also known as SEMINIFEROUS
TUBULE DYSGENESIS. This syndrome is a
genetic condition that results when a boy is born with an extra copy of the X
chromosome. It is a condition affecting males, and it often isn't diagnosed
until adulthood This is Most common sex chromosomal abnormality . Karyotype is 47 XXY (44 autosome + XX sex
chromosome +one extra Y chromosome)
Characteristics feature-
- Feminine feature in an apparent male with small testis.
- Patient is genetically female but develop male genitalia.
- Male characteristics develop due to adequate testosterone
- Mental retardation
- Primary hypogonadism and infertility
- Seminiferous tubules are not properly develop
3.Triple x syndrome:-This
is a common aberration of sexual differentiation in which the karyotype is XXX .Usually,
it is not associated with any characteristic abnormalities and therefore remains undetected.In this case
Females are known as super females.
Characteristics feature-
- Taller than the average height.
- Ovary abnormalities lead to premature ovarian failure.
- Learning difficulties in speech and language.
- In the range of low or normal intelligence.
4.TESTICULAR
FEMINIZATION SYNDROME:- The patient appear normal females externally. The
chromosome are 46 in number with XY KARYOTYPE. This is a X-Linked recessive disorder.
These are the Androgen receptor resistance-high testosterone blood level.
Characteristics feature:-
- Patient is genetically male but appears like normal female.
- Primary amenorrhea.
- no development of uterus.
- Gonads are testis with immature seminiferous tubule.
- Testis are present but spermatogenesis does not occur.
5.TRUE HERMAPHRODITISM:-This is a rare
condition in which both testis and ovaries are present.In this case karyotype is 46 (XX-XY).Sometimes , ovary is
present on one side and testis is present on the opposite side. Both male and
female sex differentiations occur with development of combined female &
male external and internal genitalia.
6.PSEUDOHERMAPHRODITISM:-A
pseudo hermaphrodite is an individual with genetic constitution and gonad of
one sex , but the external genitalia of other sex .Patients have normal gonadal
development according to their chromosome. Both male and female pseudo
hermaphrodite are present.
1.Female pseudo
hermaphroditism-
- Male external genital develop in genetic female.
- Individual posses ovary and oviduct with varying degree of masculine differentiation.
- Source of androgen is congenital virilising adrenal hyperplasia.
- Chromosomal sex is female.
2.Male pseudo hermaphroditism-
Development of female external genitalia in
genetic male.
Due to defective testicular development.
Also due to androgen resistance or due to defect
in androgen receptor.
Diagnosis of Sex Chromosomal abnormalities-Chromosomal
abnormality can be diagnosed before birth by-
- Amniocentesis
- Chorionic villi sampling
- Triple marker screening test
1.Amniocentesis- It is a procedure
in which amniotic fluid is removed from the uterus for testing or treatment.
Amniotic fluid is the fluid that surrounds and protects a baby during
pregnancy. This fluid contains fetal cells and various proteins.
2.Chorionic villus sampling (CVS)-
It is a prenatal test in which a sample of chorionic villi is removed from the
placenta for testing. The sample can be taken through the cervix (trans
cervical) or the abdominal wall (transabdominal).
1. 3.Triple
marker screening test- This is also knows as triple test or triple
screen, the Kettering test or the Bart's test. This is an investigation performed during second
trimester of pregnancy to classify a patient as either
high-risk or low-risk for chromosomal abnormalities (and neural tube defects).
Triple marker screening test is used to measure
the 3 substance
- Alpha- fetoprotein
- Human chorionic gonadotrophin
- Estradiol.
Sex chromosomal abnormalities are rare seen in human population.Chromosomal
error prevent a foetus from developing normally and because of this abnormality
miscarraige occur in 1st trimester of pregnancy.
Dr. Ajay Kumar Singh was born on
2 Dec,1981 in HOLY DISTRICT PRAYAGRAJ. He is an alumnus of
GSVM Medical College Kanpur and
MLN Medical College Allahabad. He worked for 13 years in the Uttar Pradesh Provincial services as Medical Officer.
He offered his services at various place like Community Health Center, Police Hospital, and Jail Hospital. He is a social thinker and writer. He is always ready to deliver his services to the needy person and patient. He works with the motto of making the healthy and happy society.
Wednesday, January 15, 2020
Gout
क्या है गठिया?
गठिया को हम आम भाषा में “जोड़ो का दर्द” कहते है। दरअसल मेडिकल भाषा में जब हड्डियों के जोडो़ में यूरिक एसिड इकठ्ठा होने लगता है तब वह गठिया कहलाता है। इसके साथ ही जोड़ों में दर्द, अकड़न, सूजन, गांठ और शूल चुभने जैसी पीड़ा उत्पन होने लगती है।
अर्थराइटिस के
प्रकार
·
रूमेटॉयड अर्थराइटिस: यह बहुत अधिक पाया जाने वाला गठिया का गंभीर रूप
है जो शरीर की प्रतिरक्षा प्रणाली उपास्थि (ऊतक जोड़ों को एक साथ जोड़ती है) पर
हमला करती है।
·
सोराइटिक अर्थराइटिस: अर्थराइटिस के दर्द का यह रूप प्रायः सोरायसिस
नामक त्वचा संक्रमण के कारण होता है जो समय पर इलाज न होने पर काफी घातक और लाइलाज हो
जाती है।
·
ओस्टियोसोराइसिस: यह बीमारी आनुवांशिक हो सकता है जो नसों और अस्थिरज्जु, उपास्थि और
जोड़ो की अंतर्निहित हड्डियों पर बुरा प्रभाव डालता है। । यह उम्र बीतने के साथ
प्रकट होता है। यह बीमारी अक्सर शरीर का
भार सहन करने वाले अंगों जैसे पीठ, कमर, घुटना, रीढ़, अंगूठे का जोड़ और पैर की अंगुलियों को
प्रभावित करता है।
·
पोलिमायलगिया रूमेटिका: यह गठिया का प्रकार अक्सर 50 साल की आयु
पार कर चुके लोगों में होता है। इसमें गर्दन, कंधा और कमर
में असहनीय पीड़ा होने के साथ साथ इन अंगों को घुमाने में कठिनाई होती है।
·
एनकायलाजिंग स्पोंडिलाइटिस: यह सामान्यत: पीठ और शरीर के
निचले हिस्से के जोड़ों को प्रभावित करती है। इसमें दर्द हल्का होता है लेकिन
लगातार बना रहता है।
·
गाउट या गांठ: जब जोड़ों में मोनोसोडियम युरेट क्रिस्टल समाप्त हो जाता है तब वह
गांठ वाली गठिया का रूप ले लेता है। इस बीमारी में भोजन में बदलाव जरुरी होता है और
कुछ दवाओं की सहायता से कुछ दिन में आराम हो जाता है ।
·
सिडडोगाउट: यह रूमेटायड और गाउट से मिलता जुलता गठिया का प्रकार है जिसमे जोडों
में कैल्शियम पाइरोफासफेट या हाइड्रोपेटाइट क्रिस्टल जमा हो जाते है।
·
सिस्टेमिक लयूपस अर्थिमेटोसस: यह एक ऑटो इम्यून बीमारी है जो
जोड़ों के साथ साथ त्वचा और अन्य अंगों को प्रभावित करती है। यह बच्चे पैदा करने
वाली उम्र में महिलाओं को होती है।
गठिया के लक्षण-
·
जोड़ों में दर्द या अकड़न
·
जोड़ों में सूजन या फुलाव
·
चलने-फिरने या हिलने-डुलने में परेशानी
·
प्राय शुरुआत में ये लक्षण घुटनों, नितंबों, उंगलियों तथा मेरू की हड्डियों दिखते है
·
समय से इलाज न होने पर कलाइयों, कोहनियों, कंधों तथा टखनों के जोड़ों में भी ये लक्षण दिखाई पड़ने लगते है
गठिया के कारक-
·
महिलाओं में एस्ट्रोजन की कमी
·
शरीर में आयरन की अधिकता
·
शरीर में कैल्सियम की अधिकता
·
पोषण की कमी
·
मोटापा
·
संक्रमण
·
ज्यादा शराब पीना
·
हाई ब्लड प्रेशर
·
किडनियों को ठीक प्रकार से काम ना करना
·
वंशानुगत
गठिया का उपचार कैसे करे?
·
गठिया के उचित उपचार के लिए चिकित्सक से जरुर परामर्श ले। चिकित्सक आपका रक्त परीक्षण और एक्स-रे करा सकते है। चिकित्सक द्वारा निर्देशित दवाइयां का नियमित रूप से सेवन करे।
- शारीरिक वजन पर नियंत्रण रखें।
·
पौष्टिक आहार का सेवन करें।
·
चिकित्सक द्वारा निर्देशित व्यायाम या योग नियमित रूप से करें।
·
समुचित विश्राम करें।
·
आप हलकी मालिश भी कर सकते है।
·
आप हीटिंग पैड और आईस पैक का भी प्रयोग
कर जोड़ों और मांसपेशियों के दर्द से बच सकते हैं।
- आप एक्यूपंक्चर
का भी सहारा ले सकते है। इस चिकित्सा में त्वचा के प्रभावित बिंदुओं पर शुद्ध
सुइयों को चुभो कर गठिया के दर्द को ठीक करा जाता है।
Labels:
Disease
Dr. Ajay Kumar Singh was born on
2 Dec,1981 in HOLY DISTRICT PRAYAGRAJ. He is an alumnus of
GSVM Medical College Kanpur and
MLN Medical College Allahabad. He worked for 13 years in the Uttar Pradesh Provincial services as Medical Officer.
He offered his services at various place like Community Health Center, Police Hospital, and Jail Hospital. He is a social thinker and writer. He is always ready to deliver his services to the needy person and patient. He works with the motto of making the healthy and happy society.
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